Rheumatol Int. 2011 Apr;31(4):529-32. Epub 2009 Oct 22.

Development of antisynthetase syndrome in a patient with rheumatoid arthritis.

Park CK, Kim TJ, Cho YN, Kim IS, Lee HJ, Lee KE, Park SC, Kim JS, Park DJ, Lee SJ, Seo SR, Kim JC, Song SG, Lee SS, Park YW.

Source

Department of Rheumatology, Chonnam National University Medical School and Hospital, 8 Hak-dong, Dong-ku, Gwangju 501-757, Republic of Korea.

Abstract

Rheumatoid arthritis (RA) and antisynthetase syndrome (ASS) are distinct clinical syndromes, and their co-occurrence is rarely encountered. The authors report the case of a 56-year-old female patient with RA of 3 years duration who suddenly developed ASS, and include a review of the literature. The patient was diagnosed with ASS based on; positivity for anti-histidyl-tRNA synthetase (Jo-1) antibody, interstitial lung disease, polyarthritis, and mechanic's hands. High-dose corticosteroid and pulse intravenous cyclophosphamide were used to control the ASS. This case demonstrates that ASS should be considered during clinical presentations due to its potential overlap with RA.

Comment in

Rheumatol Int. 2011 May;31(5):705-6.

PMID:: 19847427; [PubMed - indexed for MEDLINE]

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Antisynthetase syndrome

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