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Diabetes Care. 2010 Feb;33(2):270-2. doi: 10.2337/dc09-1002. Epub 2009 Oct 21.

Glycated albumin and glycated hemoglobin are influenced differently by endogenous insulin secretion in patients with type 2 diabetes.

Author information

  • 1Department of Internal Medicine, Kinki Central Hospital, Itami, Hyogo, Japan. koga_m@kich.itami.hyogo.jp

Abstract

OBJECTIVE:

Glycated albumin (GA) relative to A1C is a useful marker of short-term glycemic control. We investigated whether endogenous insulin secretion in type 2 diabetes has different effects on GA and A1C levels.

RESEARCH DESIGN AND METHODS:

A1C, GA, and GA-to-A1C ratio were compared in 202 type 2 diabetic patients by type of treatment. Effect of beta-cell function determined by homeostasis model assessment (HOMA-%beta) on GA-to-A1C ratio was examined. In addition, GA-to-A1C ratio was compared between type 2 diabetic patients and 16 patients with type 1 diabetes.

RESULTS:

In type 2 diabetic patients, GA-to-A1C ratio was significantly higher in those treated with insulin than in those treated with diet or oral hypoglycemic agents. HOMA-%beta showed a significant inverse correlation with GA-to-A1C ratio. This ratio was higher in type 1 diabetic patients than in type 2 diabetic patients.

CONCLUSIONS:

In diabetic patients with decreased insulin secretion, serum GA levels are higher relative to A1C.

PMID:
19846794
[PubMed - indexed for MEDLINE]
PMCID:
PMC2809261
Free PMC Article
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