Send to

Choose Destination
See comment in PubMed Commons below
Am J Transplant. 2009 Dec;9(12):2736-44. doi: 10.1111/j.1600-6143.2009.02847.x. Epub 2009 Oct 21.

Regulatory T-cell counter-regulation by innate immunity is a barrier to transplantation tolerance.

Author information

  • 1Division of Surgery, Department of Transplantation, Massachusetts General Hospital, Boston, MA, USA.


Innate immune signals foster adaptive immunity through activation of antigen-presenting cells. Recent in vitro evidence suggests that innate signaling may also contribute to immunity by countering the effects of regulatory T cells (T-regs), counter-regulation. We present in vivo evidence using a transgenic skin allograft model that the function of T-regs is lost in the setting of acute skin transplantation but remains intact when grafts were transplanted 1 month prior to allow surgery-induced inflammation to abate. Our findings identify T-reg counter-regulation as a naturally occurring process that accompanies transplantation and an important barrier to T-reg-mediated tolerance. Our finding further highlights the central role of regulatory cell deactivation in the initiation of the immune response.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Write to the Help Desk