Nano Lett. 2009 Dec;9(12):4412-6.

Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo.

Lee S, Ryu JH, Park K, Lee A, Lee SY, Youn IC, Ahn CH, Yoon SM, Myung SJ, Moon DH, Chen X, Choi K, Kwon IC, Kim K.

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Biomedical Research Center, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 136-791, Korea.

Abstract

We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.

PMID:: 19842672; [PubMed - indexed for MEDLINE]

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