Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 2009 Oct 29;461(7268):1234-42. doi: 10.1038/nature08403. Epub 2009 Oct 18.

What recent ribosome structures have revealed about the mechanism of translation.

Author information

  • 1MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. schmeing@mrc-lmb.cam.ac.uk

Abstract

The high-resolution structures of ribosomal subunits published in 2000 have revolutionized the field of protein translation. They facilitated the determination and interpretation of functional complexes of the ribosome by crystallography and electron microscopy. Knowledge of the precise positions of residues in the ribosome in various states has facilitated increasingly sophisticated biochemical and genetic experiments, as well as the use of new methods such as single-molecule kinetics. In this review, we discuss how the interaction between structural and functional studies over the last decade has led to a deeper understanding of the complex mechanisms underlying translation.

PMID:
19838167
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk