Cell Host Microbe. 2009 Oct 22;6(4):292-4.

Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1.

Source

Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Monoclonal antibodies that effectively neutralize HIV-1 have been widely sought, yet few have been isolated. Now, technological advances in sera evaluation, B cell stimulation, microneutralization, and antibody cloning have allowed Burton and colleagues to identify two broadly neutralizing monoclonal antibodies, PG9 and PG16, which provide insights for HIV vaccine design.

PMID:: 19837366; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

AIDS/HIV. A boost for HIV vaccine design. [Science. 2010]
AIDS/HIV. A boost for HIV vaccine design.
Burton DR, Weiss RA. Science. 2010 Aug 13; 329(5993):770-3.
Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1. [J Virol. 2010]
Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
Pancera M, McLellan JS, Wu X, Zhu J, Changela A, Schmidt SD, Yang Y, Zhou T, Phogat S, Mascola JR, et al. J Virol. 2010 Aug; 84(16):8098-110. Epub 2010 Jun 10.
Broad neutralization coverage of HIV by multiple highly potent antibodies. [Nature. 2011]
Broad neutralization coverage of HIV by multiple highly potent antibodies.
Walker LM, Huber M, Doores KJ, Falkowska E, Pejchal R, Julien JP, Wang SK, Ramos A, Chan-Hui PY, Moyle M, et al. Nature. 2011 Sep 22; 477(7365):466-70.
Review Specificities of broadly neutralizing anti-HIV-1 sera. [Curr Opin HIV AIDS. 2009]
Review Specificities of broadly neutralizing anti-HIV-1 sera.
Binley J. Curr Opin HIV AIDS. 2009 Sep; 4(5):364-72.
Review Antibody polyspecificity and neutralization of HIV-1: a hypothesis. [Hum Antibodies. 2005]
Review Antibody polyspecificity and neutralization of HIV-1: a hypothesis.
Haynes BF, Moody MA, Verkoczy L, Kelsoe G, Alam SM. Hum Antibodies. 2005; 14(3-4):59-67.

See reviews... See all...

Cited by 2 PubMed Central articles

HIV-1 superinfection in women broadens and strengthens the neutralizing antibody response. [PLoS Pathog. 2012]
HIV-1 superinfection in women broadens and strengthens the neutralizing antibody response.
Cortez V, Odem-Davis K, McClelland RS, Jaoko W, Overbaugh J. PLoS Pathog. 2012 Mar; 8(3):e1002611. Epub 2012 Mar 29.
Review Rational antibody-based HIV-1 vaccine design: current approaches and future directions. [Curr Opin Immunol. 2010]
Review Rational antibody-based HIV-1 vaccine design: current approaches and future directions.
Walker LM, Burton DR. Curr Opin Immunol. 2010 Jun; 22(3):358-66. Epub 2010 Mar 17.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to H...
Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1.
Cell Host Microbe. 2009 Oct 22 ;6(4):292-4.

PubMed
Adolescent immunization delivery in school-based health centers: a national surv...
Adolescent immunization delivery in school-based health centers: a national survey.
J Adolesc Health. 2009 Nov ;45(5):445-52. Epub 2009 May 30 .

PubMed
Patient-centered communication to assess and enhance patient adherence to glauco...
Patient-centered communication to assess and enhance patient adherence to glaucoma medication.
Ophthalmology. 2009 Nov ;116(11 Suppl):S37-42.

PubMed
Adverse health effects of non-medical cannabis use.
Adverse health effects of non-medical cannabis use.
Lancet. 2009 Oct 17 ;374(9698):1383-91.

PubMed
Multidisciplinary treatment of fibromyalgia: does cognitive behavior therapy inc...
Multidisciplinary treatment of fibromyalgia: does cognitive behavior therapy increase the response to treatment?
J Psychosom Res. 2009 Nov ;67(5):433-41. Epub 2009 Mar 6 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: