Br J Oral Maxillofac Surg. 2010 Apr;48(3):221-3.

Osteonecrosis of the jaws induced by anti-RANK ligand therapy.

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Pinderfields General Hospital, Wakefield, West Yorkshire, United Kingdom. k.h.taylor@leeds.ac.uk

Abstract

Since the introduction of bisphosphonates to treat diseases that affect remodelling of bone, increasing numbers of patients with bisphosphonate-related osteonecrosis of the jaws have been reported; the number is currently unknown. Recently anti-RANKL agents (receptor activator of nuclear factor-kappaB ligand) such as denosumab (Prolia, Amgen Inc., California, USA) that have a similar mode of action to bisphosphonates have been introduced to treat such diseases. We report a case of osteonecrosis that was induced by anti-RANKL therapy. To our knowledge this is the first case to have been induced by these agents.

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