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Contraception. 2009 Nov;80(5):422-9. doi: 10.1016/j.contraception.2009.03.007. Epub 2009 May 2.

The association between use of spermicides or male condoms and major structural birth defects.

Author information

  • 1School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. shayne.gallaway@us.army.mil

Abstract

BACKGROUND:

Women may become pregnant while using contraceptives. Commonly used contraceptives containing spermicides may or may not be associated with an increased occurrence of structural birth defects.

STUDY DESIGN:

Utilizing data from the National Birth Defects Prevention Study, we assessed maternal reports of spermicide and male condom use 1 to 3 months following conception among case (n=11,050) and control (n=4723) mothers. We assessed the association between spermicide use and 27 types of birth defects and that between condom use and 32 types of birth defects.

RESULTS:

Maternal spermicide use during the first 3 months following conception was associated with a significant increase in the occurrence of only 1 of 27 birth defects, perimembranous ventricular septal defects (adjusted odds ratio=2.40, 95% confidence interval=1.25-4.62). There was no significant association between maternal use of male condoms during the first 3 months following conception and any of 32 types of birth defects.

CONCLUSIONS:

The increased occurrence of perimembranous ventricular septal defects among spermicide users may be real or may be a chance finding. Overall, the findings are consistent with those of most previous studies that observed no increased risk for birth defects among spermicide users.

PMID:
19835715
[PubMed - indexed for MEDLINE]
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