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Brief Funct Genomic Proteomic. 2009 Nov;8(6):437-43. doi: 10.1093/bfgp/elp041.

Annotating non-coding transcription using functional genomics strategies.

Author information

  • 1Omics Science Center, RIKEN Yokohama Institute, Yokohama, Kanagawa 230-0045 Japan.

Abstract

Non-coding RNA (ncRNA) transcripts are RNA molecules that do not code for proteins, but elicit function by other mechanisms. The vast majority of RNA produced in a cell is non-coding ribosomal RNA, produced from relatively few loci, however more recently complementary DNA (cDNA) cloning, tag sequencing, and genome tiling array studies suggest that ncRNAs also account for the majority of RNA species produced by a cell. ncRNA based regulation has been referred to as a 'hidden layer' of signals or 'dark matter' that control gene expression in cellular processes by poorly described mechanisms. These terms have appeared as ncRNAs until recently have been ignored by expression profiling and cDNA annotation projects and their mode of action is diverse (e.g. influencing chromatin structure and epigenetics, translational silencing, transcriptional silencing). Here, we highlight recent functional genomics strategies toward identifying and assigning function to ncRNA transcription.

PMID:
19833699
[PubMed - indexed for MEDLINE]
PMCID:
PMC2762128
Free PMC Article
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