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J Neuroimmunol. 2009 Dec 10;217(1-2):90-4. doi: 10.1016/j.jneuroim.2009.09.017. Epub 2009 Oct 14.

Managing non-paraneoplastic Lambert-Eaton myasthenic syndrome: clinical characteristics in 25 German patients.

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  • 1Institute for Clinical Neuroimmunology, Ludwig Maximilians University of Munich, 81377 Munich, Germany.


In about 40% of patients LEMS is not a paraneoplastic phenomenon (NT-LEMS). Several clinical aspects important to these patients remain open, especially the question when a LEMS can definitely be diagnosed as NT-LEMS. Here we describe a series of 25 German NT-LEMS patients regarding their clinical characteristics, duration of symptoms, value of serological markers, paraneoplastic antibodies and FDG-PET/CT. Furthermore, we discuss the current diagnostic criteria of NT-LEMS.

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