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Cardiol Rev. 2009 Nov-Dec;17(6):283-6. doi: 10.1097/CRD.0b013e3181b3fe0d.

The emerging role of apelin in cardiovascular disease and health.

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  • 1Department of Radiology, Barnes-Jewish Hospital, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.


This article focuses on a newly discovered bioactive peptide, termed apelin, as it relates to the cardiovascular system. Apelin, through its G-protein coupled receptor, seems to primarily exert effects in blood pressure control, and may play a role in heart failure and in myocardial reperfusion injury. In addition, at least some of apelin's effects appear to stem from an interaction with the renin-angiotensin system. Apelin may provide a target for drug treatment of cardiovascular disease.

[PubMed - indexed for MEDLINE]
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