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J Pediatr Hematol Oncol. 2009 Nov;31(11):870-2. doi: 10.1097/MPH.0b013e3181b7eda2.

Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease.

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  • 1Division of Hematology and Oncology, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.


Ceftriaxone-induced hemolytic anemia is a rare and often fatal phenomenon. We report here the case of a 6-year-old female with sickle cell disease who survived a brisk and profound hemolytic reaction, resulting in hemoglobin of 0.4 g/dL, after ceftriaxone infusion. Ongoing hemolysis was abrogated with aggressive supportive care, but the patient suffered extensive neurologic sequelae as a result of the event. Serologic testing confirmed the presence of ceftriaxone antibodies.

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