Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J R Soc Interface. 2010 May 6;7(46):755-64. doi: 10.1098/rsif.2009.0393. Epub 2009 Oct 14.

Distribution of vaccine/antivirals and the 'least spread line' in a stratified population.

Author information

  • 1Harvard School of Public Health, Boston, MA 02115, USA. egoldste@hsph.harvard.edu

Abstract

We describe a prioritization scheme for an allocation of a sizeable quantity of vaccine or antivirals in a stratified population. The scheme builds on an optimal strategy for reducing the epidemic's initial growth rate in a stratified mass-action model. The strategy is tested on the EpiSims network describing interactions and influenza dynamics in the population of Utah, where the stratification we have chosen is by age (0-6, 7-13, 14-18, adults). No prior immunity information is available, thus everyone is assumed to be susceptible-this may be relevant, possibly with the exception of persons over 50, to the 2009 H1N1 influenza outbreak. We have found that the top priority in an allocation of a sizeable quantity of seasonal influenza vaccinations goes to young children (0-6), followed by teens (14-18), then children (7-13), with the adult share being quite low. These results, which rely on the structure of the EpiSims network, are compared with the current influenza vaccination coverage levels in the US population.

PMID:
19828505
[PubMed - indexed for MEDLINE]
PMCID:
PMC2874227
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1.
Figure 2.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk