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Epilepsy Res. 2009 Dec;87(2-3):286-9. doi: 10.1016/j.eplepsyres.2009.09.011. Epub 2009 Oct 13.

Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex.

Author information

  • 1Department of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, NH, USA. olena.isaeva@gmail.com

Abstract

Here we studied the long-term effects of neonatal seizures on inhibitory synaptic transmission in somatosensory cortex. We found that recurrent flurothyl-induced seizures result in a marked reduction in amplitude of spontaneous inhibitory postsynaptic currents (IPSCs) and increases of miniature IPSCs interevent intervals. These results indicate that decreasing the inhibitory synaptic strength following neonatal seizures in neocortical neurons is not due to a postsynaptic mechanism.

PMID:
19828295
[PubMed - indexed for MEDLINE]
PMCID:
PMC2788005
Free PMC Article

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