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Acta Psychiatr Scand. 2010 May;121(5):351-8. doi: 10.1111/j.1600-0447.2009.01483.x. Epub 2009 Oct 13.

Illicit substance use and its correlates in first episode psychosis.

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  • 1Department of Medicine and Public Health, University of Verona, Italy. rodolfo.mazzoncini@univr.it <rodolfo.mazzoncini@univr.it>

Abstract

OBJECTIVE:

To determine if substance use (particularly cannabis) is more frequent among first episode psychosis patients and associated with a more problematic clinical presentation.

METHOD:

All first episode psychosis (FEP) patients presenting to secondary services were recruited from London and Nottingham, over 2 years, in the Aetiology and Ethnicity of Schizophrenia and Other Psychoses study broad framework. Clinical and sociodemographic variables were assessed using a set of standardized instruments. A schedule was created to retrospectively collate substance use data from patients, relatives and clinicians.

RESULTS:

Five hundred and eleven FEP were identified. They used three to five times more substances than general population. Substance use was associated with poorer social adjustment and a more acute mode of onset. Cannabis use did not affect social adjustment, but was associated with a more acute mode of onset.

CONCLUSION:

Cannabis has a different impact on FEP than other substances. Large epidemiological studies are needed to disentangle cannabis effect.

PMID:
19824986
[PubMed - indexed for MEDLINE]
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