Abstract
Electrochemically modified carbon-fiber electrodes were used to assess the effects of indirect (amphetamine and GBR-12909) as well as direct D1 (SKF-38393) and D2 (quinpirole) dopamine agonists on extracellular ascorbate in the neostriatum of awake, behaving rats. Relative to controls, 2.5 mg/kg d-amphetamine and 20.0 mg/kg GBR-12909 produced marked behavioral activation concomitant with a significant increase in ascorbate. Comparable effects were observed following the combined administration of 10.0 mg/kg SKF-38393 and 1.0 mg/kg quinpirole, but not after either of these drugs alone. Thus, behavioral activation and release of neostriatal ascorbate were closely related to the concurrent stimulation of both D1 and D2 dopamine receptors.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
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Amphetamine / pharmacology
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Animals
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Ascorbic Acid / metabolism*
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Behavior, Animal / drug effects*
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism*
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Dopamine Agents / pharmacology
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Electrochemistry
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Electrodes
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Ergolines / pharmacology
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Male
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Neurotransmitter Uptake Inhibitors / pharmacology
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Piperazines / pharmacology
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Quinpirole
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / drug effects*
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Stereotaxic Techniques
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Stimulation, Chemical
Substances
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Dopamine Agents
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Ergolines
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Neurotransmitter Uptake Inhibitors
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Piperazines
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Receptors, Dopamine
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Quinpirole
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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vanoxerine
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Amphetamine
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Ascorbic Acid