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J Gerontol A Biol Sci Med Sci. 2010 Jan;65(1):93-8. doi: 10.1093/gerona/glp151. Epub 2009 Oct 12.

How does change in depressive symptomatology influence weight change in patients with diabetes? Observational results from the Pathways longitudinal cohort.

Author information

  • 1Group Health Research Institute, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101, USA. ludman.e@ghc.org

Abstract

BACKGROUND:

Little is known about how change in depressive symptoms over time is associated with change in weight.

METHODS:

Longitudinal associations between change in depression (Patient Health Questionnaire-9 [PHQ-9]) and weight (self-reported and chart abstracted) were examined in 2,600 patients with type 2 diabetes (mean age 62, SD = 11.6) who were surveyed by telephone in 2001-2002 and 5 years later as part of the Pathways study. Mixed effects regression analyses compared a) patients with persistently low depression symptoms with those whose depression worsened (increased at least 5 points on PHQ-9) over 5 years and b) patients with persistently high depression symptoms with those who improved (decreased at least 5 points on PHQ-9) over 5 years.

RESULTS:

Those who worsened in comparison to those with persistently low depression symptoms did not differ in their pattern of weight change (z = 1.54, p = .12). Both groups weighed approximately 92 kg at baseline and lost approximately 2 kg. A significantly different pattern of change over time was observed for those with persistently high depression symptoms in comparison to those whose depression improved (z = 1.98, p = .04). Although the groups had almost identical weight at baseline (approximately 100 kg), at the 5-year assessment, those with persistently high depression symptoms had about half the weight loss (M = -1.71, SD = 9.08) in comparison to those whose depression improved (M = -3.62, SD = 19.93).

CONCLUSION:

In persons with diabetes who have clinically significant levels of depressive symptoms, improvement in depression is accompanied by significantly greater, clinically significant weight loss.

PMID:
19822623
[PubMed - indexed for MEDLINE]
PMCID:
PMC2796881
Free PMC Article
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