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J Physiol. 2010 Jan 1;588(Pt 1):93-9. doi: 10.1113/jphysiol.2009.179382. Epub 2009 Oct 12.

Activity-dependent synaptic plasticity of NMDA receptors.

Author information

  • 1Laboratoire Physiologie Cellulaire de la Synapse, CNRS, Bordeaux Neuroscience Institute, University of Bordeaux, 33077 Bordeaux Cedex, France.

Abstract

Activity-dependent, bidirectional control of synaptic efficacy is thought to contribute to many forms of experience-dependent plasticity, including learning and memory. Although most excitatory synapses contain both AMPA and N-methyl-d-aspartate receptors (AMPARs and NMDARs), most studies have focused on the plasticity of synaptic AMPARs, and on the pivotal role of NMDA receptors for its induction. Here we review evidence that synaptic NMDARs themselves are subject to long-term activity-dependent changes by mechanisms that may differ from that of synaptic AMPARs. The bidirectional modulation of NMDAR-mediated synaptic responses is likely to have important functional implications for NMDAR-dependent forms of synaptic plasticity.

PMID:
19822542
[PubMed - indexed for MEDLINE]
PMCID:
PMC2821550
Free PMC Article

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