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Nat Genet. 2009 Nov;41(11):1170-2. doi: 10.1038/ng.462. Epub 2009 Oct 11.

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.

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  • 1Department of Epidemiology and Public Health, Imperial College London, London, UK. john.chambers@ic.ac.uk

Abstract

We carried out a genome-wide association study of hemoglobin levels in 16,001 individuals of European and Indian Asian ancestry. The most closely associated SNP (rs855791) results in nonsynonymous (V736A) change in the serine protease domain of TMPRSS6 and a blood hemoglobin concentration 0.13 (95% CI 0.09-0.17) g/dl lower per copy of allele A (P = 1.6 x 10(-13)). Our findings suggest that TMPRSS6, a regulator of hepcidin synthesis and iron handling, is crucial in hemoglobin level maintenance.

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PMID:
19820698
[PubMed - indexed for MEDLINE]
PMCID:
PMC3178047
Free PMC Article
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