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    Trends Cardiovasc Med. 2009 May;19(4):135-40.

    Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation.

    Morris AJ, Selim S, Salous A, Smyth SS.

    Source

    The Gill Heart Institute, University of Kentucky College of Medicine, Lexington, KY 40536, USA. a.j.morris@uky.edu

    Abstract

    Lysophosphatidic acid and sphingosine 1-phosphate are bioactive lipid mediators with potent effects on cardiovascular development and vascular function. New studies define dynamic mechanisms that maintain physiologically relevant levels of both lipids in the blood. We review the mechanisms controlling the production, metabolism, and distribution of these lipids between vascular cells, circulating blood components, and the plasma.

    PMID:
    19818950
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2761247
    Free PMC Article

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