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Exp Gerontol. 2010 Apr;45(4):279-85. doi: 10.1016/j.exger.2009.10.001. Epub 2009 Oct 8.

Role of HDAC1 in senescence, aging, and cancer.

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  • 1Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.


HDAC1 is a member of the class I of histone deacetylases that also includes HDAC2, -3 and -8. Although HDAC1 has been mostly studied in the context of cancer, recent evidence strongly suggests that it plays critical roles in cellular senescence, aging of the liver, myelination, and adult neurogenesis. Here we review such roles and discuss the entangled relationships between HDAC1 with histone acetyltransferases and other HDACs including SIRT1.

2009 Elsevier Inc. All rights reserved.

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