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Clin Cardiol. 2009 Nov;32(11):E63-6. doi: 10.1002/clc.20467.

Nonapical tako-tsubo cardiomyopathy associated with coronary slow flow: a case report and review of the literature.

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  • 1Department of Cardiovascular Sciences, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Groby Road, Leicester LE3 9QP, United Kingdom. uk12@le.ac.uk


The exact pathophysiology of tako-tsubo cardiomyopathy (TTC) is unclear. A nonapical form of TTC precipitated by emotional stress is presented. Findings on 12 lead ECG and coronary angiogram are discussed. The role of specialized investigations such as cardiac MRI and tissue Doppler imaging are reviewed. We then examine the probable molecular explanations for this condition and suggest a probable molecular mechanism based on animal studies. Future therapeutic options are also briefly discussed.

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