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Int Urogynecol J. 2010 Jan;21(1):111-6. doi: 10.1007/s00192-009-0995-6. Epub 2009 Oct 9.

Effects of soy isoflavones on the uterus and urethra of ovariectomized rats.

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  • 1Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil. etravaglia@uol.com.br

Abstract

OBJECTIVE:

To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats.

METHODS:

Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 microg genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI).

RESULTS:

Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF.

CONCLUSIONS:

Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration.

[PubMed - indexed for MEDLINE]
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