Format

Send to:

Choose Destination
See comment in PubMed Commons below
PLoS One. 2009 Oct 9;4(10):e7396. doi: 10.1371/journal.pone.0007396.

Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex.

Author information

  • 1Brain Research centre Antwerp for Innovative and Interdisciplinary Neuromodulation (BRAI(2)N), University Hospital Antwerp, Antwerp, Belgium. elsa.vanderloo@ua.ac.be

Abstract

BACKGROUND:

Non-pulsatile tinnitus is considered a subjective auditory phantom phenomenon present in 10 to 15% of the population. Tinnitus as a phantom phenomenon is related to hyperactivity and reorganization of the auditory cortex. Magnetoencephalography studies demonstrate a correlation between gamma band activity in the contralateral auditory cortex and the presence of tinnitus. The present study aims to investigate the relation between objective gamma-band activity in the contralateral auditory cortex and subjective tinnitus loudness scores.

METHODS AND FINDINGS:

In unilateral tinnitus patients (N = 15; 10 right, 5 left) source analysis of resting state electroencephalographic gamma band oscillations shows a strong positive correlation with Visual Analogue Scale loudness scores in the contralateral auditory cortex (max r = 0.73, p<0.05).

CONCLUSION:

Auditory phantom percepts thus show similar sound level dependent activation of the contralateral auditory cortex as observed in normal audition. In view of recent consciousness models and tinnitus network models these results suggest tinnitus loudness is coded by gamma band activity in the contralateral auditory cortex but might not, by itself, be responsible for tinnitus perception.

PMID:
19816597
[PubMed - indexed for MEDLINE]
PMCID:
PMC2754613
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk