Mol Chem Neuropathol. 1990 Mar;12(2):121-9; discussion 143-5.

Arylsulfatase A (ASA) defect and psychiatric illness. A review.

Source

University of California, San Francisco, Brain-Behavior Research Center, Sonoma Development Center, Eldridge 95431.

Abstract

The detection of homozygous (disease state) and heterozygous (carrier) forms of metachromatic leukodystrophy (MLD) and their prevalence among psychiatric individuals are reviewed. Levels of Arylsulfatase A (ASA) activity in peripheral leukocytes, mixed white cell populations, and lymphocytes are compared in normal and psychiatric patients. The prevalence of low levels of enzyme activity in psychiatric patients, and the implications of such levels with regard to the metabolic disease states and associated psychiatric illnesses are discussed. In addition, the use and reliability of leukocyte enzyme assay systems as a criteria for determining and distinguishing between the homozygous and heterozygous conditions are evaluated.

PMID:: 1981468; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Cerebroside-Sulfatase

Grant Support

S07-RR05755/RR/NCRR NIH HHS/United States

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Arylsulfatase A (ASA) defect and psychiatric illness. A review.
Arylsulfatase A (ASA) defect and psychiatric illness. A review.
Mol Chem Neuropathol. 1990 Mar ;12(2):121-9; discussion 143-5.

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