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Diagn Interv Radiol. 2010 Mar;16(1):16-9. doi: 10.4261/1305-3825.DIR.1708-08.1. Epub 2009 Oct 5.

A rare case of multiple sclerosis and cerebral hemorrhage associated with osteopetrosis.

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  • 1Department of Neurology, Acibadem University School of Medicine, Istanbul, Turkey.


Osteopetrosis, or Albers-Schönberg disease, is a rare hereditary disease characterized by osteoclast dysfunction and consequent diminished bone resorption and disturbed bone building and remodeling, resulting in abnormally dense and brittle bones. Bone marrow failure, pathologic fractures, and neurologic deficits are common. Osteopetrosis is diagnosed on radiographs. Patients have generalized osteosclerosis, and radiographs may show evidence of fractures. We report a case of cerebral hemorrhage and multiple sclerosis associated with the benign adult form of osteopetrosis.

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