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Antivir Ther. 2009;14(6):731-8. doi: 10.3851/IMP1253.

Host genetics influences on HIV type-1 disease.

Author information

  • Center for Human Genome Variation, Institute for Genome Sciences & Policy, Duke University, Durham, NC, USA. jcf20@duke.edu


HIV host genetic studies seek to describe as comprehensively as possible the effect of human genetic variation on the individual response to HIV type-1 (HIV-1) infection. Many associations between specific gene variants and HIV-1 disease outcomes have been reported over the past 15 years. Although most of them have yet to be confirmed or have been proven false-positives, the identification of several definitive genotype-phenotype associations has shed new light on HIV-1 pathogenesis. This review discusses these results in the context of the new genome-wide approaches that now make it possible to globally assess the influence of the host genome on HIV-1-related outcomes.

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