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Autoimmunity. 2009 May;42(4):373-5.

Do B cells play a role in the pathogenesis of juvenile idiopathic arthritis?

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  • 1Pediatric Rheumatology, Immunology and Infectious Diseases, Children's Hospital, University of W├╝rzburg, W├╝rzburg, Germany.


Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of diseases. The role of B cells (BC) in autoimmune diseases has been put in a new perspective due to the promising results of BC depleting therapies in RA. Experiments in mouse models have shed new light on the Ab-independent role of BC in the pathogenesis of autoimmune diseases. We discuss whether BC play a role in the pathogenesis of JIA appraising the question for an immunological basis of BC directed therapy.

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