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Assignment of the polymorphic intestinal mucin gene (MUC2) to chromosome 11p15.
MRC Human Biochemical Genetics Unit, University College London.
A cDNA coding for a mucin expressed in intestine has recently been cloned (Gum et al. 1989). We describe here the use of this cDNA to map the gene (MUC2) to human chromosome 11 using somatic cell hybrids, and to make the regional localization to 11p15 by in situ hybridization. Analysis of the CEPH (Centre d'Etude du Polymorphisme Humain) families revealed that MUC2 forms part of the tight linkage group on 11p15 which contains HRAS, INS, TH and HBBC.
PMID: 1980995 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family.
Buisine MP, Desseyn JL, Porchet N, Degand P, Laine A, Aubert JP.
Biochem J. 1998 Jun 15; 332 ( Pt 3):729-38.
[Biochem J. 1998]
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MUC1 expressed in PanC1 cells decreases adhesion to type 1 collagen but increases contraction in collagen lattices.
Hudson MJ, Stamp GW, Hollingsworth MA, Pignatelli M, Lalani EN.
Am J Pathol. 1996 Mar; 148(3):951-60.
[Am J Pathol. 1996]
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Suggestive evidence for two different mucin genes in rat intestine.
Khatri IA, Forstner GG, Forstner JF.
Biochem J. 1993 Sep 1; 294 ( Pt 2):391-9.
[Biochem J. 1993]
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