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Lung. 2010 Jan;188 Suppl 1:S19-22. doi: 10.1007/s00408-009-9187-x. Epub 2009 Oct 7.

Nitric oxide measurement in chronic cough.

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  • 1Department of Medicine, Division of Pulmonary and Critical Care, Mayo Clinic Rochester, 200 First Street Gonda 18-417, Rochester, MN, 55905, USA, lim.kaiser@mayo.edu.


Chronic cough is a common symptom-based diagnostic challenge for primary care physicians and respiratory specialists. Measurement of exhaled nitric oxide is a convenient, reproducible, and inexpensive point-of-service test. It can simplify the evaluation process of chronic cough by providing information regarding the state of airway inflammation. If exhaled nitric oxide is elevated, this is predictive of a favorable response to inhaled corticosteroids. This has the effect of reducing empirical trials for cough-variant asthma or eosinophilic bronchitis. The inclusion of exhaled nitric oxide in the diagnostic approach to chronic cough should be considered.

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