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BMJ. 2009 Oct 6;339:b3928. doi: 10.1136/bmj.b3928.

Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City.

Author information

  • 1Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico.

Abstract

OBJECTIVE:

To evaluate the association of 2008-9 seasonal trivalent inactivated vaccine with cases of influenza A/H1N1 during the epidemic in Mexico.

DESIGN:

Frequency matched case-control study.

SETTING:

Specialty hospital in Mexico City, March to May 2009.

PARTICIPANTS:

60 patients with laboratory confirmed influenza A/H1N1 and 180 controls with other diseases (not influenza-like illness or pneumonia) living in Mexico City or the State of Mexico and matched for age and socioeconomic status.

MAIN OUTCOME MEASURES:

Odds ratio and effectiveness of trivalent inactivated vaccine against influenza A/H1N1.

RESULTS:

Cases were more likely than controls to be admitted to hospital, undergo invasive mechanical ventilation, and die. Controls were more likely than cases to have chronic conditions that conferred a higher risk of influenza related complications. In the multivariate model, influenza A/H1N1 was independently associated with trivalent inactivated vaccine (odds ratio 0.27, 95% confidence interval 0.11 to 0.66) and underlying conditions (0.15, 0.08 to 0.30). Vaccine effectiveness was 73% (95% confidence interval 34% to 89%). None of the eight vaccinated cases died.

CONCLUSIONS:

Preliminary evidence suggests some protection from the 2008-9 trivalent inactivated vaccine against pandemic influenza A/H1N1 2009, particularly severe forms of the disease, diagnosed in a specialty hospital during the influenza epidemic in Mexico City.

Comment in

PMID:
19808768
[PubMed - indexed for MEDLINE]
PMCID:
PMC2758337
Free PMC Article
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