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Cell Metab. 2009 Oct;10(4):241-2. doi: 10.1016/j.cmet.2009.09.003.

Does hypothalamic inflammation cause obesity?

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  • 1Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195, USA.


Obesity-induced inflammation causes cellular resistance to both insulin and leptin. In this issue, BrĂ¼ning and colleagues (Kleinridders et al., 2009) add to growing evidence that this response occurs in the hypothalamus, as well as in peripheral tissues, which helps to explain how high-fat feeding induces a gradual increase in defended body weight.

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