Nano Lett. 2009 Dec;9(12):4434-40.

A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles.

Tromsdorf UI, Bruns OT, Salmen SC, Beisiegel U, Weller H.

Source

Institute of Physical Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany. ulrich.tromsdorf@chemie.uni-hamburg.de

Abstract

In this study we systematically developed a potential MR T(1) contrast agent based on very small PEGylated iron oxide nanoparticles. We adjusted the size of the crystalline core providing suitable relaxometric properties. In addition, a dense and optimized PEG coating provides high stability under physiological conditions together with low cytotoxicity and low nonspecific phagocytosis into macrophage cells as a part of the reticulo endothelial system at biologically relevant concentrations. The as developed contrast agent has the lowest r(2)/r(1) ratio (2.4) at 1.41 T reported so far for PEGylated iron oxide nanoparticles as well as a r(1) relaxivity (7.3 mM(-1) s(-1)) that is two times higher compared to that of Magnevist as a typical T(1) contrast agent based on gadolinium as a clinical standard.

PMID:: 19799448; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

MRI Scans - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T1- and T2-weighted magnetic resonance imaging. [Nanotechnology. 2011]
Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T1- and T2-weighted magnetic resonance imaging.
Hu F, Jia Q, Li Y, Gao M. Nanotechnology. 2011 Jun 17; 22(24):245604. Epub 2011 Apr 21.
Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution T1 magnetic resonance imaging contrast agents. [J Am Chem Soc. 2011]
Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution T1 magnetic resonance imaging contrast agents.
Kim BH, Lee N, Kim H, An K, Park YI, Choi Y, Shin K, Lee Y, Kwon SG, Na HB, et al. J Am Chem Soc. 2011 Aug 17; 133(32):12624-31. Epub 2011 Jul 25.
Synthesis and characterization of PEGylated Gd2O3 nanoparticles for MRI contrast enhancement. [Langmuir. 2010]
Synthesis and characterization of PEGylated Gd2O3 nanoparticles for MRI contrast enhancement.
Ahrén M, Selegård L, Klasson A, Söderlind F, Abrikossova N, Skoglund C, Bengtsson T, Engström M, Käll PO, Uvdal K. Langmuir. 2010 Apr 20; 26(8):5753-62.
Review Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy. [Int J Nanomedicine. 2008]
Review Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy.
Peng XH, Qian X, Mao H, Wang AY, Chen ZG, Nie S, Shin DM. Int J Nanomedicine. 2008; 3(3):311-21.
Review MR and iron magnetic nanoparticles. Imaging opportunities in preclinical and translational research. [Tumori. 2008]
Review MR and iron magnetic nanoparticles. Imaging opportunities in preclinical and translational research.
Neumaier CE, Baio G, Ferrini S, Corte G, Daga A. Tumori. 2008 Mar-Apr; 94(2):226-33.

See reviews... See all...

Cited by 4 PubMed Central articles

Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting. [Biomaterials. 2011]
Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting.
Cole AJ, David AE, Wang J, Galbán CJ, Hill HL, Yang VC. Biomaterials. 2011 Mar; 32(8):2183-93. Epub 2010 Dec 21.
On Ultrasmall Nanocrystals. [Chem Phys Lett. 2010]
On Ultrasmall Nanocrystals.
McBride JR, Dukes AD 3rd, Schreuder MA, Rosenthal SJ. Chem Phys Lett. 2010 Sep 30; 498(1-3):1-9.
Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles. [ACS Nano. 2010]
Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles.
Huang J, Bu L, Xie J, Chen K, Cheng Z, Li X, Chen X. ACS Nano. 2010 Dec 28; 4(12):7151-60. Epub 2010 Nov 2.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated ...
A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles.
Nano Lett. 2009 Dec ;9(12):4434-40.

PubMed
[Antiradiation effects of lactoferrin].
[Antiradiation effects of lactoferrin].
Radiats Biol Radioecol. 2009 Jul-Aug ;49(4):456-61.

PubMed
[Salmonellosis in Poland in 2007].
[Salmonellosis in Poland in 2007].
Przegl Epidemiol. 2009 ;63(2):229-35.

PubMed
Genome-wide high-resolution chromatin immunoprecipitation of meiotic chromosomal...
Genome-wide high-resolution chromatin immunoprecipitation of meiotic chromosomal proteins in Saccharomyces cerevisiae.
Methods Mol Biol. 2009 ;557:285-304.

PubMed
Modulating and targeting meiotic double-strand breaks in Saccharomyces cerevisia...
Modulating and targeting meiotic double-strand breaks in Saccharomyces cerevisiae.
Methods Mol Biol. 2009 ;557:27-33.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information