Adv Exp Med Biol. 2009;653:117-28.

Target pattern recognition by complement proteins of the classical and alternative pathways.

Kang YH, Tan LA, Carroll MV, Gentle ME, Sim RB.

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MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, UK.

Abstract

The complement system is a major component of the innate defence of animals against invading microorganisms, and is also essential for the recognition and clearance of damaged or structurally-altered host cells or macromolecules. The system is activated by three different pathways, each of which responds, using different recognition molecules, to a very wide range of activators. The recognition protein of the complement classical pathway, C1q is described in detail here, with comparisons to the alternative pathway.

PMID:: 19799115; [PubMed - indexed for MEDLINE]

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