Sense and serendipity aid RPE generation

Cell Stem Cell. 2009 Oct 2;5(4):347-8. doi: 10.1016/j.stem.2009.09.011.

Abstract

Retinal pigment epithelium (RPE) is a valuable cell type for a number of blinding disorders. In this issue of Cell Stem Cell, Idelson et al. (2009) use Nicotinamide and Activin A to markedly improve RPE yield from human embryonic stem cells.

Publication types

  • Comment

MeSH terms

  • Activin Receptors, Type I / pharmacology
  • Activin Receptors, Type II / pharmacology
  • Activins / pharmacology
  • Animals
  • Cell Differentiation / drug effects
  • Cell Line
  • Cell Transplantation
  • Embryonic Stem Cells / cytology*
  • Embryonic Stem Cells / drug effects
  • Embryonic Stem Cells / ultrastructure
  • Epithelial Cells / cytology*
  • Epithelial Cells / drug effects
  • Epithelial Cells / ultrastructure
  • Fibroblast Growth Factor 2 / pharmacology
  • Humans
  • Rats
  • Retinal Pigment Epithelium / cytology*
  • Transforming Growth Factor beta / pharmacology

Substances

  • Transforming Growth Factor beta
  • activin A
  • Fibroblast Growth Factor 2
  • Activins
  • Activin Receptors, Type I
  • Activin Receptors, Type II