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Org Biomol Chem. 2009 Oct 21;7(20):4163-5. doi: 10.1039/b911483a. Epub 2009 Aug 7.

Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine.

Author information

  • 1Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA. pwipf@pitt.edu

Abstract

Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF5-substituted quinolines.

PMID:
19795052
[PubMed - indexed for MEDLINE]
PMCID:
PMC2929370
Free PMC Article

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