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    Curr Genomics. 2009 Apr;10(2):93-101.

    Current Screens Based on the AlphaScreen Technology for Deciphering Cell Signalling Pathways.

    Taouji S, Dahan S, Bossé R, Chevet E.

    Source

    Avenir, INSERM U889, Montreal, Qc, Canada.

    Abstract

    Global deciphering of signal transduction pathways represents a new challenge of the post-genomic era. However, for the majority of these signaling pathways the role(s), the function(s) and the interaction(s) of the signaling intermediates remain to be characterized in an integrated fashion. The global molecular study of cell signaling pathways and networks consequently requires sensitive, robust technologies which may allow in addition multi-parallel and highthroughput applications. The Alphascreen technology, relying on a bead-based homogenous approach, constitutes a valuable tool to detect and quantify a wide range of signaling events such as enzymatic activities or biomolecular interactions. In this article, we exhaustively review the literature and report the broad spectrum of Alphascreen-based applications in the study of signal transduction pathways.

    PMID:
    19794881
    [PubMed]
    PMCID:
    PMC2699825
    Free PMC Article

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    Fig. (2)
    Fig. (1)
    Fig. (3). Schematic representation of a canonical signaling pathway “from the plasma membrane to the nucleus”.

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