Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Diab Rep. 2009 Oct;9(5):348-54.

Treating diabetes and prediabetes by focusing on obesity management.

Author information

  • 1Boston University School of Medicine, Center for Nutrition and Weight Management, Boston Medical Center, Boston, MA 02118, USA.

Abstract

Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes mellitus (T2DM). In obesity, the adipose cell releases nonesterified free fatty acids, hormones, adipocytokines, and other substances that are involved in insulin resistance. Under normal conditions, the pancreatic islet beta cells increase production of insulin sufficiently to maintain normal blood glucose concentrations despite insulin resistance. However, in genetically predisposed patients, the beta cells eventually become dysfunctional and T2DM develops. The development of T2DM can be delayed or sometimes prevented in individuals with obesity who are able to lose weight. Weight loss can be achieved medically with behavioral therapies that combine diet and exercise treatment or with behavioral therapies combined with weight-loss medications or weight-loss surgery. In this article, we summarize the evidence of obesity management in treating T2DM and prediabetes.

PMID:
19793504
[PubMed - indexed for MEDLINE]
PMCID:
PMC2857968
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk