Abstract
Three types of T cell receptors (TcR) gamma/delta were identified in swine, all of which are disulfide-bonded cell surface heterodimers. The first, a 38/40-kDa molecule, is related to the TcR gamma/delta of sheep and cattle, and defines in swine a subset of CD4-CD8- T lymphocytes that is enriched in the circulating T lymphocyte pool. The other two receptors are private to swine. The second, a 37/40-kDa molecule, is expressed by the major subset of CD2-CD4-CD8- T lymphocytes that is neither enriched in nor excluded from lymphoid tissue. By contrast, the third type of TcR gamma/delta, a 40/46-kDa molecule, is found on CD2+CD4-CD8- T lymphocytes accumulating in lymphoid tissue. Thus, TcR gamma/delta T lymphocyte subsets differing in homing propensity are typified by the expression of distinct molecular forms of the TcR gamma/delta.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antigens, Differentiation, T-Lymphocyte / immunology
-
Antigens, Differentiation, T-Lymphocyte / physiology
-
CD2 Antigens
-
CD4 Antigens / immunology
-
CD4 Antigens / physiology
-
CD8 Antigens
-
Cell Movement
-
Cell Separation
-
Disulfides
-
Electrophoresis, Polyacrylamide Gel
-
Flow Cytometry
-
Lymphoid Tissue / cytology*
-
Mesentery / cytology
-
Mesentery / immunology
-
Receptors, Antigen, T-Cell / immunology
-
Receptors, Antigen, T-Cell / physiology*
-
Receptors, Antigen, T-Cell, gamma-delta
-
Receptors, Immunologic / immunology
-
Receptors, Immunologic / physiology
-
Spleen / cytology
-
Spleen / immunology
-
Swine
-
T-Lymphocyte Subsets / immunology
-
T-Lymphocyte Subsets / physiology*
Substances
-
Antigens, Differentiation, T-Lymphocyte
-
CD2 Antigens
-
CD4 Antigens
-
CD8 Antigens
-
Disulfides
-
Receptors, Antigen, T-Cell
-
Receptors, Antigen, T-Cell, gamma-delta
-
Receptors, Immunologic