Format

Send to:

Choose Destination
See comment in PubMed Commons below
Epilepsy Behav. 2009 Nov;16(3):461-7. doi: 10.1016/j.yebeh.2009.08.022. Epub 2009 Sep 27.

Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?

Author information

  • 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. mpavlova1@partners.org

Abstract

Epileptiform abnormalities often occur at specific times of day or night, possibly attributable to state of consciousness (sleep vs. wake) and/or influences from the endogenous circadian pacemaker. In this pilot study we tested for the existence of circadian variation of interictal epileptiform discharges (IEDs), independent of changes in state, environment, or behavior. Five patients with generalized epilepsy underwent a protocol whereby their sleep/wake schedule was evenly distributed across the circadian cycle while undergoing full-montage electroencephalography and hourly plasma melatonin measurements. Light was <8 lux to prevent circadian entrainment. All patients completed the protocol, testifying to its feasibility. All patients had normal circadian rhythmicity of plasma melatonin relative to their habitual sleep times. In the three patients with sufficient IEDs to assess variability, most IEDs occurred during non-rapid eye movement (NREM) sleep (ratio NREM:wake=14:1, P<0.001). In both patients who had NREM at all circadian phases, there was apparent circadian variation in IEDs but with different phases relative to peak melatonin.

PMID:
19786369
[PubMed - indexed for MEDLINE]
PMCID:
PMC3861150
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk