Send to

Choose Destination
See comment in PubMed Commons below
Ned Tijdschr Geneeskd. 2009;153:A330.

[Oral blood glucose-lowering medication as a monotherapy in gestational diabetes: a hotly debated topic].

[Article in Dutch]

Author information

  • 1Universitair Medisch Centrum Utrecht, afd. Interne Geneeskunde, Utrecht, The Netherlands.


Treatment of gestational diabetes mellitus is a hotly debated topic. In a recent randomized trial, metformin as a monotherapy achieved maternal and neonatal outcomes comparable to insulin treatment. In 2000, a randomized trial reported a similar favourable result with glibenclamide. The logical conclusion would be that either drug could already have a place in the usual treatment strategy in gestational diabetes. However, a number of major methodological, design and interpretation issues and shortcomings have led to the conclusion that such a point of view is not currently tenable. Therefore, neither metformin nor glibenclamide can yet have an established place as monotherapies in gestational diabetes; they can be used only in exceptionally cases.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk