Molecules. 2009 Sep 17;14(9):3621-61.

Medicinal chemistry of Annonaceous acetogenins: design, synthesis, and biological evaluation of novel analogues.

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Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, Japan. kojima@phs.osaka-u.ac.jp

Abstract

Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an alpha,beta-unsaturated gamma-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues.

PMID:: 19783948; [PubMed - indexed for MEDLINE]

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