Tuberculosis (Edinb). 2009 Sep;89(5):354-63. Epub 2009 Sep 26.

Antituberculosis activity of the molecular libraries screening center network library.

Maddry JA, Ananthan S, Goldman RC, Hobrath JV, Kwong CD, Maddox C, Rasmussen L, Reynolds RC, Secrist JA 3rd, Sosa MI, White EL, Zhang W.

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Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA. maddry@southernresearch.org

Abstract

There is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant forms of the disease. One approach to addressing this need is through high-throughput screening of drug-like small molecule libraries against the whole bacterium in order to identify a variety of new, active scaffolds that will stimulate additional biological research and drug discovery. Through the Molecular Libraries Screening Center Network, the NIAID Tuberculosis Antimicrobial Acquisition and Coordinating Facility tested a 215,110-compound library against Mycobacterium tuberculosis strain H37Rv. A medicinal chemistry survey of the results from the screening campaign is reported herein.

PMID:: 19783214; [PubMed - indexed for MEDLINE]
PMCID:: PMC2792876

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