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Int J Hyg Environ Health. 2010 Jan;213(1):44-51. doi: 10.1016/j.ijheh.2009.09.001. Epub 2009 Sep 26.

Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos.

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  • 1Center of Epidemiology, BGFA - Research Institute of Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr University Bochum, Germany.


The objective of this analysis was the estimation of the cancer risks of asbestos and asbestosis in a surveillance cohort of high-exposed German workers. A group of 576 asbestos workers was selected for high-resolution computer tomography of the chest in 1993-1997. A mortality follow-up was conducted through 2007. Standardised mortality ratios (SMRs) were calculated and Poisson regression was performed to assess mesothelioma risks. A high risk was observed for pleural mesothelioma (SMR 28.10, 95% CI 15.73-46.36) that decreased after cessation of exposure (RR 0.1; 95% CI 0.0-0.6 for > or =30 vs. <30 years after last exposure). Asbestosis was a significant risk factor for mesothelioma (RR 6.0, 95% CI 2.4-14.7). Mesothelioma mortality was still in excess in former asbestos workers although decreasing after cessation of exposure. Fibrosis was associated with subsequent malignancy.

Copyright 2009 Elsevier GmbH. All rights reserved.

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