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Int J Hyg Environ Health. 2010 Jan;213(1):44-51. doi: 10.1016/j.ijheh.2009.09.001. Epub 2009 Sep 26.

Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos.

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  • 1Center of Epidemiology, BGFA - Research Institute of Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr University Bochum, Germany. pesch@bgfa.de

Abstract

The objective of this analysis was the estimation of the cancer risks of asbestos and asbestosis in a surveillance cohort of high-exposed German workers. A group of 576 asbestos workers was selected for high-resolution computer tomography of the chest in 1993-1997. A mortality follow-up was conducted through 2007. Standardised mortality ratios (SMRs) were calculated and Poisson regression was performed to assess mesothelioma risks. A high risk was observed for pleural mesothelioma (SMR 28.10, 95% CI 15.73-46.36) that decreased after cessation of exposure (RR 0.1; 95% CI 0.0-0.6 for > or =30 vs. <30 years after last exposure). Asbestosis was a significant risk factor for mesothelioma (RR 6.0, 95% CI 2.4-14.7). Mesothelioma mortality was still in excess in former asbestos workers although decreasing after cessation of exposure. Fibrosis was associated with subsequent malignancy.

Copyright 2009 Elsevier GmbH. All rights reserved.

PMID:
19783208
[PubMed - indexed for MEDLINE]
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