Format

Send to

Choose Destination
See comment in PubMed Commons below
Dev Biol. 2009 Dec 1;336(1):76-83. doi: 10.1016/j.ydbio.2009.09.032. Epub 2009 Sep 25.

Mammalian Merkel cells are descended from the epidermal lineage.

Author information

  • 1Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA.

Abstract

Merkel cells are specialized cells in the skin that are important for proper neural encoding of light touch stimuli. Conflicting evidence suggests that these cells are lineally descended from either the skin or the neural crest. To address this question, we used epidermal (Krt14(Cre)) and neural crest (Wnt1(Cre)) Cre-driver lines to conditionally delete Atoh1 specifically from the skin or neural crest lineages, respectively, of mice. Deletion of Atoh1 from the skin lineage resulted in loss of Merkel cells from all regions of the skin, while deletion from the neural crest lineage had no effect on this cell population. Thus, mammalian Merkel cells are derived from the skin lineage.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk