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Mol Cell. 2009 Sep 24;35(6):735-6. doi: 10.1016/j.molcel.2009.09.012.

Destruction of RhoA CULtivates actin.

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  • 1Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA. shdwu@burnham.org

Abstract

Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation, thereby maintaining actin cytoskeleton integrity.

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PMID:
19782022
[PubMed - indexed for MEDLINE]
PMCID:
PMC3981991
Free PMC Article

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