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Vet Microbiol. 2010 Jan 27;140(3-4):246-55. doi: 10.1016/j.vetmic.2009.08.028. Epub 2009 Aug 28.

Zoonotic aspects of rotaviruses.

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  • 1Department of Veterinary Public Health, University of Bari, Bari, Italy. v.martella@veterinaria.uniba.it

Abstract

Rotaviruses are important enteric pathogens of humans and animals. Group A rotaviruses (GARVs) account for up to 1 million children deaths each year, chiefly in developing countries and human vaccines are now available in many countries. Rotavirus-associated enteritis is a major problem in livestock animals, notably in young calves and piglets. Early in the epidemiological GARV studies in humans, either sporadic cases or epidemics by atypical, animal-like GARV strains were described. Complete genome sequencing of human and animal GARV strains has revealed a striking genetic heterogeneity in the 11 double stranded RNA segments across different rotavirus strains and has provided evidence for frequent intersections between the evolution of human and animal rotaviruses, as a result of multiple, repeated events of interspecies transmission and subsequent adaptation.

Copyright 2009 Elsevier B.V. All rights reserved.

PMID:
19781872
[PubMed - indexed for MEDLINE]
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