Send to

Choose Destination
See comment in PubMed Commons below
Urology. 2010 Nov;76(5):1042-6. doi: 10.1016/j.urology.2009.05.100. Epub 2009 Sep 25.

Association between glomerular filtration rate, free, total, and percent free prostate-specific antigen.

Author information

  • 1Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.



To determine the relationship between glomerular filtration rate (GFR) and free prostate-specific antigen (fPSA), percent-free PSA (%fPSA), and total PSA (tPSA) in patients with diminished kidney function not on dialysis, using nationally representative data.


A total of 3782 men aged ≥ 40 years who participated in the National Health and Nutrition Examination Survey 2001-2006, and who met eligibility criteria for PSA testing were included in the final study population. GFR (mL/min/1.73 m(2)) was calculated using the Modification of Diet in Renal Disease equation 7 and categorized as ≥ 90, 60 to < 90, and 15 to < 60. Distribution of tPSA, fPSA, and %fPSA were estimated by GFR category and by age and race. Multivariate linear regression models were fit to determine the adjusted relationship between GFR and tPSA and %fPSA after adjusting for age, race, and body mass index.


The multivariate linear regression analysis showed that GFR had a linear relationship with tPSA that was of borderline significance. There was a significant nonlinear relationship between GFR and %fPSA (P < .001): increased GFR was associated with a decrease in %fPSA for GFR levels below 90 [eg, change in %fPSA = -2.67 (95% CI -3.56, -1.77) for a GFR of 85 as compared with 65; P < .001]. The decline in %fPSA with increasing GFR was nonsignificant for GFR levels above 90.


Our finding that renal function as measured by GFR is negatively associated with %fPSA has potential implications for use of this test in men with renal disease.

Published by Elsevier Inc.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk