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Lancet. 1990 Dec 1;336(8727):1360-2.

Angiotensin-converting-enzyme inhibitors and anaphylactoid reactions to high-flux membrane dialysis.

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  • 1Department of Nephrology, Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium.


In a retrospective study, 9 of 236 haemodialysis patients treated with high-flux polyacrylonitrile 'AN 69' membranes were found to have had anaphylactoid reactions. Treatment with angiotensin-converting-enzyme (ACE) inhibitors had been recently started in all 9 affected patients; only 5 of 227 unaffected patients had been treated with ACE inhibitors, and anaphylactoid reactions disappeared after discontinuation of ACE inhibitors.

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