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Res Microbiol. 2009 Nov;160(9):687-95. doi: 10.1016/j.resmic.2009.09.006. Epub 2009 Sep 22.

The role of proteolysis in the Caulobacter crescentus cell cycle and development.

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  • 1Biozentrum of the University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.


Caulobacter crescentus cell cycle progression is implemented by oscillating global transcriptional regulators that establish temporal and spatial control of modular genetic subsystems during the cell cycle. The hierarchy of this regulatory circuit is established through a combination of gene expression control and regulated proteolysis. Recent results highlight the importance of spatial organization for controlled proteolysis in C. crescentus.

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